反应详情

To a suspension of isophthalic acid (500 g, 3 mol) in methanol (2.8) was added 5% Rhodium-on-alumina catalyst (50 g) and acetic acid (150 ml). The reaction mixture was shaken under hydrogen (50 psi) at room temperature overnight. The mixture was filtered through celite. To this solution was added fresh 5% Rhodium-on-alumina catalyst (25 g), and the mixture was shaken under 50 psi of hydrogen for another 24 hours. The final reaction mixture was filtered through celite. The solution was concentrated under vacuum to give 493 g of the title compound as a white powder (96.3% yield). m.p. 163-165° C.

1. filtrationThe mixture was filtered through celite
2. additionTo this solution was added fresh 5% Rhodium-on-alumina catalyst (25 g)
3. stirringthe mixture was shaken under 50 psi of hydrogen for another 24 hours
4. customThe final reaction mixture
5. filtrationwas filtered through celite
6. concentrationThe solution was concentrated under vacuum