反应详情

To a stirred solution of 3-methoxyphenethylamine (56.6 g, 0.37 m) and triethylamine (38.0 g, 0.38 m) in CHCl3 (900 ml) was added acetyl chloride (33.0 g, 0.42 m) dropwise over a period of 30 minutes at 20°-25° C., and then the reaction was stirred overnight. The mixture was extracted with 500 ml ice water, then extracted further with 2×500 ml cold water. The chloroform layer was dried over MgSO4 and concentrated to N-acetyl-3-methoxyphenethylamine as an oil (90 g).

1. extractionThe mixture was extracted with 500 ml ice water
2. extractionextracted further with 2×500 ml cold water
3. dry with materialThe chloroform layer was dried over MgSO4
4. concentrationconcentrated to N-acetyl-3-methoxyphenethylamine as an oil (90 g)