cis-1-Benzyl-2,6-dimethylpiperazine → cis-7-(4-Benzyl-3,5-dimethylpiperazin-1-yl)-6-methoxyquinoline

HRID 352363Notes

Reaction equation

HRID 352363 reaction equation
[CH2:1]([N:8]1[C@H:13]([CH3:14])[CH2:12][NH:11][CH2:10][C@@H:9]1[CH3:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:17]1[CH:26]=[C:25]2[C:20]([CH:21]=[CH:22][CH:23]=[N:24]2)=[CH:19][C:18]=1[O:27][CH3:28]>>[CH2:1]([N:8]1[C@@H:13]([CH3:14])[CH2:12][N:11]([C:17]2[CH:26]=[C:25]3[C:20]([CH:21]=[CH:22][CH:23]=[N:24]3)=[CH:19][C:18]=2[O:27][CH3:28])[CH2:10][C@H:9]1[CH3:15])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 12284911cis-1-Benzyl-2,6-dimethylpiperazineHCID 145668977-Bromo-6-methoxyquinoline

Product 1

HCID 69837656cis-7-(4-Benzyl-3,5-dimethylpiperazin-1-yl)-6-methoxyquinoline

Procedure

The title compound was prepared from cis-1-benzyl-2,6-dimethylpiperazine (Org. Prep. Proc. 1976, 8, 19) and 7-bromo-6-methoxyquinoline (J. Org. Chem. 1990, 55, 2019) using a similar procedure to Description 2 (75%).

Sources & evidence

ORD record
ord-366abd74ab324242870f5e3b0ea0df0c
Source dataset
uspto-grants-2004_06
Patent number
US06747030B1

Reaction notes

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