2-Fluoro-3-(trifluoromethyl)phenylacetic acid → HCID 44402887, compound

HRID 352369Notes

Reaction equation

HRID 352369 reaction equation
[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:12][C:13]([OH:15])=O.[CH3:16][O:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][C:26]=1[N:27]1[CH2:32][C@H:31]([CH3:33])[N:30]([CH3:34])[C@H:29]([CH3:35])[CH2:28]1)[NH:23][CH2:22][CH2:21]2>>[F:1][C:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:12][C:13]([N:23]1[C:24]2[C:20](=[CH:19][C:18]([O:17][CH3:16])=[C:26]([N:27]3[CH2:32][C@H:31]([CH3:33])[N:30]([CH3:34])[C@H:29]([CH3:35])[CH2:28]3)[CH:25]=2)[CH2:21][CH2:22]1)=[O:15]

Participants

3

Reactant 2

HCID 27375882-Fluoro-3-(trifluoromethyl)phenylacetic acidHCID 69836129cis-5-Methoxy-6-(3,4,5-trimethylpiperazin-1-yl)indoline

Product 1

HCID 44402887HCID 44402887, compound

Procedure

The title compound was prepared from 2-fluoro-3-trifluoromethylphenylacetic acid (155 mg, 0.70 mmole) and D3 (150 mg, 0.54 mmole) using a similar procedure to Example 8. The product was obtained as a pale yellow oil (210 mg, 81%), which was converted to its hydrochloride salt as a beige solid.

Sources & evidence

ORD record
ord-c5d20f0c98624bae96a6bcc57e721702
Source dataset
uspto-grants-2004_06
Patent number
US06747030B1

Reaction notes

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