Water → 3-(2-Chloro-6-fluorophenyl)-5-acetylisoxazole

HRID 35245Notes

Reaction equation

HRID 35245 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[CH:13]=[C:12]([CH:14]([OH:16])[CH3:15])[O:11][N:10]=1.O>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[CH:13]=[C:12]([C:14](=[O:16])[CH3:15])[O:11][N:10]=1

Participants

4

Reactant 2

HCID 962WaterHCID 148146851-[3-(2-Chloro-6-fluorophenyl)-5-isoxazolyl]-ethanol

Product 1

HCID 148146863-(2-Chloro-6-fluorophenyl)-5-acetylisoxazole

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Conditions

Temperature
5 °C

Procedure

To a solution of 30 g (124 mmol) of 1-[3-(2-chloro-6-fluorophenyl)-5-isoxazolyl]-ethanol in 187 ml of acetic acid maintained under stirring at 5° C. were added dropwise 9.07 (90.7 mmol) of CrO3 in 9.34 of water and 132 ml of acetic acid.

Sources & evidence

ORD record
ord-46bd94bcb7bf45a7a2e065bbd4e8d3ea
Source dataset
uspto-grants-1988_08
Patent number
US04766137

Reaction notes

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