Thiourea → 2-Amino-4-(3-bromo-5-isoxazolyl)-thiazole

HRID 35246Notes

Reaction equation

HRID 35246 reaction equation
Br[CH2:2][C:3]([C:5]1[O:9][N:8]=[C:7]([Br:10])[CH:6]=1)=O.[NH2:11][C:12]([NH2:14])=[S:13]>C(O)C>[NH2:14][C:12]1[S:13][CH:2]=[C:3]([C:5]2[O:9][N:8]=[C:7]([Br:10])[CH:6]=2)[N:11]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 136269733-Bromo-5-(bromoacetyl)isoxazole

Product 1

HCID 148146982-Amino-4-(3-bromo-5-isoxazolyl)-thiazole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 32.4 g (120.4 mol) of 5-bromoacetyl-3-bromoisoxazole and 18.4 g (240 mmol) of thiourea in 400 ml of anhydrous ethanol was refluxed for 90 minutes.

Workup

  1. temperaturewas refluxed for 90 minutes

Sources & evidence

ORD record
ord-9644ee042c6549bb8ea8936e03738844
Source dataset
uspto-grants-1988_08
Patent number
US04766137

Reaction notes

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