4-Nitrobenzaldehyde → HCID 3754851, compound

HRID 352538Notes

Reaction equation

HRID 352538 reaction equation
[Cl:1][C:2]1[C:3]2[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[C:7]([NH:9][NH2:10])=[O:8].[N+:15]([C:18]1[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=1)([O-:17])=[O:16]>C(O)C>[N+:15]([C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[N:10][NH:9][C:7]([C:6]2[S:5][C:4]3[CH:11]=[CH:12][CH:13]=[CH:14][C:3]=3[C:2]=2[Cl:1])=[O:8])=[CH:20][CH:19]=1)([O-:17])=[O:16]

Participants

4

Reactant 2

HCID 5414-NitrobenzaldehydeHCID 6069253-Chloro-1-benzothiophene-2-carbohydrazide

Product 1

HCID 3754851HCID 3754851, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-chlorobenzo[b]thiophene-carboxylic acid hydrazide (34 mg, 0.15 mmol) and p-nitrobenzaldehyde (23 mg, 0.15 mmol) in ethanol (10 mL) was refluxed for 6 h. The precipitate was collected by filtration and washed with ethanol, dried to give 36 mg (67%) of the title compound. 1H NMR (DMSO-d6): 12.40 (bs, 1H), 8.60−7.60 (m, 9H).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with ethanol
  3. customdried

Sources & evidence

ORD record
ord-28334961c61649bb8c88349a83ac876e
Source dataset
uspto-grants-2004_06
Patent number
US06747052B2

Reaction notes

Loading…