Methyl beta-alanate → 3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(2-hydroxycarbonylethylamino)pyridine

HRID 352543Notes

Reaction equation

HRID 352543 reaction equation
C[O:2][C:3](=[O:7])[CH2:4][CH2:5][NH2:6].[Cl:8][C:9]1[C:10]([F:34])=[N:11][C:12](NCC(OC)=O)=[C:13]([Cl:27])[C:14]=1[O:15][C:16]1[CH:21]=[CH:20][C:19]([O:22]C)=[C:18]([CH:24]([CH3:26])[CH3:25])[CH:17]=1>>[Cl:8][C:9]1[C:10]([F:34])=[N:11][C:12]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:7])=[C:13]([Cl:27])[C:14]=1[O:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[C:18]([CH:24]([CH3:26])[CH3:25])[CH:17]=1

Participants

3

Reactant 2

HCID 192794Methyl beta-alanateHCID 98881843,5-Dichloro-2-fluoro-4-(3-isopropyl-4-methoxyphenoxy)-6-methoxycarbonylmethylamino-pyridine

Product 1

HCID 129878723,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(2-hydroxycarbonylethylamino)pyridine

Procedure

By use of β-alanine methyl ester in place of glycine methyl ester for the preparation of Compound 1e followed by deprotection as described for example 2.

Sources & evidence

ORD record
ord-3a76cde958dd49338121be94969bbe4f
Source dataset
uspto-grants-2004_06
Patent number
US06747048B2

Reaction notes

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