HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl beta-alanate → 3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(2-hydroxycarbonylethylamino)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl beta-alanate | HCID 192794 | — |
| Reactant | 3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-methoxyphenoxy)-6-methoxycarbonylmethylamino-pyridine | HCID 9888184 | — |
| Product | 3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(2-hydroxycarbonylethylamino)pyridine | HCID 12987872 | — |
Reaction Steps
By use of β-alanine methyl ester in place of glycine methyl ester for the preparation of Compound 1e followed by deprotection as described for example 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06747048B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-3a76cde958dd49338121be94969bbe4f |
| Source note | uspto-grants-2004_06 |