HCID 12987870, compound → HCID 22712093, compound

HRID 352548Notes

Reaction equation

HRID 352548 reaction equation
[Cl:1][C:2]1[C:3]([F:25])=[N:4][C:5]([NH:20][CH2:21][C:22](O)=[O:23])=[C:6]([Cl:19])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([CH:16]([CH3:18])[CH3:17])[CH:10]=1.CC(C[Al]CC(C)C)C>C1COCC1>[Cl:1][C:2]1[C:3]([F:25])=[N:4][C:5]([NH:20][CH2:21][CH2:22][OH:23])=[C:6]([Cl:19])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([CH:16]([CH3:18])[CH3:17])[CH:10]=1

Participants

4

Reactant 2

HCID 12987870HCID 12987870, compoundHCID 16682954Dibah

Product 1

HCID 22712093HCID 22712093, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By reduction of the methyl ester of 3,5-dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-hydroxycarbonyl-methylaminopyridine (example 2), with Dibal-H in THF.

Sources & evidence

ORD record
ord-c810ab144a56409e95625bf153d14036
Source dataset
uspto-grants-2004_06
Patent number
US06747048B2

Reaction notes

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