Chlorosulfonic acid → HCID 22712121, compound

HRID 352553Notes

Reaction equation

HRID 352553 reaction equation
[Cl:1][C:2]1[C:3]([F:19])=[N:4][C:5]([F:18])=[C:6]([Cl:17])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1.Cl[S:21]([OH:24])(=[O:23])=[O:22]>C(Cl)Cl>[Cl:1][C:2]1[C:3]([F:19])=[N:4][C:5]([F:18])=[C:6]([Cl:17])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([S:21]([OH:24])(=[O:23])=[O:22])[CH:10]=1

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 22712096HCID 22712096, compound

Product 1

HCID 22712121HCID 22712121, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3,5-Dichloro-2,6-difluoro-4-(4-methoxyphenoxy)pyridine (1.5 g, 4.9 mmol) and chlorosulfonic acid (0.39 ml, 5.8 mmol) were stirred in 5 ml of methylene chloride overnight. The resulting solid-was filtered and washed with cold CH2Cl2. Compound 43a was obtained as solid in 70% yield.

Workup

  1. filtrationThe resulting solid-was filtered
  2. washwashed with cold CH2Cl2

Sources & evidence

ORD record
ord-944459a6b15d4986bf8ac6088e6b5b6c
Source dataset
uspto-grants-2004_06
Patent number
US06747048B2

Reaction notes

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