反应详情

20% aqueous Hydrochloric acid (100 ml) is added to methyl 5-(1-phenyl-1,2,3,4-tetrazol-5-yl)valerate (9.3 g) and the mixture is refluxed for 4 hours. After cooling, water is added and the mixture is extracted with chloroform. The chloroform solution is extracted with aqueous saturated sodium bicarbonate solution. The aqueous layer is acidified with concentrated hydrochloric acid and again extracted with chloroform. The latter chloroform extract is washed with aqueous saturated sodium chloride solution and dried over magnesium sulfate. Chloroform is distilled off to give 5-(1-phenyl-1,2,3,4-tetrazol-5-yl)valeric acid (8.2 g), pale yollow liquid.

1. temperaturethe mixture is refluxed for 4 hours
2. temperatureAfter cooling
3. extractionthe mixture is extracted with chloroform
4. extractionThe chloroform solution is extracted with aqueous saturated sodium bicarbonate solution
5. extractionagain extracted with chloroform
6. extractionThe latter chloroform extract
7. washis washed with aqueous saturated sodium chloride solution
8. dry with materialdried over magnesium sulfate
9. distillationChloroform is distilled off