HCID 20732811, compound → HCID 14863951, compound

HRID 352651Notes

Reaction equation

HRID 352651 reaction equation
[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1C(OCC1C=CC=CC=1)=O>CCO.[Ni]>[CH3:1][O:2][CH:3]([O:19][CH3:20])[CH:4]1[CH2:8][CH2:7][CH2:6][NH:5]1

Participants

4

Reactant 1

HCID 20732811HCID 20732811, compound

Product 1

HCID 14863951HCID 14863951, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A solution of acetal 15 (5.8 9, 0.02 mol) in EtOH (50 mL) was allowed to stir for 16 hours at room temperature over Raney nickel (0.2 g), in order to remove the trace amounts of sulphur impurities prior to hydrogenation. Excess nickel was removed by filtration through Celite.

Workup

  1. customto remove the trace amounts of sulphur impurities
  2. customExcess nickel was removed by filtration through Celite

Sources & evidence

ORD record
ord-5ffbb9d8496a4c7691dc131f96ab5b1a
Source dataset
uspto-grants-2004_06
Patent number
US06747144B1

Reaction notes

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