HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Aminobenzene-1,3-dioic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | 1,3-Benzenedicarboxylic acid, 4-amino-, 1-methyl ester | HCID 22591727 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Aminobenzene-1,3-dioic acid | HCID 11355852 | 95.7% |
Reaction Steps
6.3 g (150 mmol) of LiOH.H2O are added to a stirred solution of 15.7 g (75 mmol) of methyl 4-amino-isophtalate in 300 ml of dioxane and 1200 ml of water. The reaction mixture is heated for 1 hour to 100° C., cooled and acidified to pH=1 by the addition of concentrated HCl. A precipitate is obtained then filtered off, washed, and dried under vacuum to yield 13 g (yield=95.7%) of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06747147B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-78088589acad47cca89cd3e3791a19bc |
| Source note | uspto-grants-2004_06 |