Trifluoroacetic acid → (2S)-2-(4-Acetylamino-benzenesulfonylamino)-3-(4-(2-(1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)-ethyl)-benzoylamino)-propionic acid

HRID 352674Notes

Reaction equation

HRID 352674 reaction equation
C([O:5][C:6](=[O:43])[C@@H:7]([NH:29][S:30]([C:33]1[CH:38]=[CH:37][C:36]([NH:39][C:40](=[O:42])[CH3:41])=[CH:35][CH:34]=1)(=[O:32])=[O:31])[CH2:8][NH:9][C:10](=[O:28])[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][C:19](=[O:27])[NH:20][C:21]2[NH:22][CH2:23][CH2:24][CH2:25][N:26]=2)=[CH:13][CH:12]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[C:40]([NH:39][C:36]1[CH:35]=[CH:34][C:33]([S:30]([NH:29][C@@H:7]([CH2:8][NH:9][C:10](=[O:28])[C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][C:19](=[O:27])[NH:20][C:21]3[NH:26][CH2:25][CH2:24][CH2:23][N:22]=3)=[CH:13][CH:12]=2)[C:6]([OH:43])=[O:5])(=[O:31])=[O:32])=[CH:38][CH:37]=1)(=[O:42])[CH3:41]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 12127436(2S)-2-(4-acetylamino-benzenesulfonylamino)-3-(4-(2-(1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)-ethyl)-benzoylamino)-propionic acid tert-butyl ester

Product 1

HCID 11512407(2S)-2-(4-Acetylamino-benzenesulfonylamino)-3-(4-(2-(1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)-ethyl)-benzoylamino)-propionic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

57 mg (0.09 mmol) of (2S)-2-(4-acetylamino-benzenesulfonylamino)-3-(4-(2-(1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)-ethyl)-benzoylamino)-propionic acid tert-butyl ester was dissolved in 2 ml of dichloromethane and 2 ml of trifluoroacetic acid was added. The solution was stirred at room temperature for 3 hours. The solvent was removed in vacuo and toluene was added to the residue and then removed in vacuo. The residue was dissolved in acetonitrile/water (1/1) and lyophilized. Yield 42 mg. MS (ES+): m/e=559.2 (M+H+).

Workup

  1. customThe solvent was removed in vacuo and toluene
  2. additionwas added to the residue
  3. customremoved in vacuo
  4. dissolutionThe residue was dissolved in acetonitrile/water (1/1)

Sources & evidence

ORD record
ord-0042ae614fb44e878fc86cb502a48312
Source dataset
uspto-grants-2004_06
Patent number
US06747148B2

Reaction notes

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