反应详情

At room temperature, methyl 4-(3-pyridyl)benzoate (1.76 g) was dissolved in a mixed solvent of 1N hydrochloric acid (50 ml) and dioxane (50 ml), followed by heating under reflux for 4 hours. The solvent was then distilled off under reduced pressure. Tetrahydrofuran was added to the residue, followed by washing, whereby the title compound (1.55 g, 93%) was obtained as a colorless solid.

1. temperatureby heating
2. temperatureunder reflux for 4 hours
3. distillationThe solvent was then distilled off under reduced pressure
4. additionTetrahydrofuran was added to the residue
5. washby washing