Methanol → Methyl 4-(2-bromoacetyl)benzoate

HRID 352728Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 352728
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:14]Br.CO.O>C(O)(=O)C.Br>[Br:14][CH2:2][C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)=[O:3]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 962WaterHCID 24408BromineHCID 137990Methyl 4-acetylbenzoate

Produkt 1

HCID 13612771Methyl 4-(2-bromoacetyl)benzoateAusbeute 71 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
15 °C

Versuchsvorschrift

At 15° C., methyl 4-acetylbenzoate (2.23 g) was dissolved in a hydrobromic acid acetic acid solution (30%, 10 ml). Bromine was gradually added dropwise to the reaction mixture to maintain its temperature at 15° C. After stirring for 10 minutes, the reaction mixture was cooled to 4° C. A mixed solvent of methanol (50 ml) and water (50 ml) was added to the reaction mixture for crystallization, followed by washing with hexane. By the collection through filtration, the title compound (2.29 g, 71%) was obtained as a colorless solid.

Aufarbeitung

  1. temperaturethe reaction mixture was cooled to 4° C
  2. washby washing with hexane
  3. customBy the collection
  4. filtrationthrough filtration

Quellen und Nachweise

ORD-Eintrag
ord-a9cb4e1b76974033ace9847fa2618d0f
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06747023B1

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