Methanol → Methyl 4-(2-bromoacetyl)benzoate

HRID 352728ノート

反応式

HRID 352728 の反応式
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:14]Br.CO.O>C(O)(=O)C.Br>[Br:14][CH2:2][C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)=[O:3]

参加物

6

反応物 4

HCID 887MethanolHCID 962WaterHCID 24408BromineHCID 137990Methyl 4-acetylbenzoate

生成物 1

HCID 13612771Methyl 4-(2-bromoacetyl)benzoate収率 71%

試薬・触媒・溶媒 1

HCID 21893785Acetic Acid Mixture with Hydrobromic Acid溶媒

反応条件

温度
15 °C

実験手順

At 15° C., methyl 4-acetylbenzoate (2.23 g) was dissolved in a hydrobromic acid acetic acid solution (30%, 10 ml). Bromine was gradually added dropwise to the reaction mixture to maintain its temperature at 15° C. After stirring for 10 minutes, the reaction mixture was cooled to 4° C. A mixed solvent of methanol (50 ml) and water (50 ml) was added to the reaction mixture for crystallization, followed by washing with hexane. By the collection through filtration, the title compound (2.29 g, 71%) was obtained as a colorless solid.

後処理

  1. temperaturethe reaction mixture was cooled to 4° C
  2. washby washing with hexane
  3. customBy the collection
  4. filtrationthrough filtration

出典と根拠

ORDレコード
ord-a9cb4e1b76974033ace9847fa2618d0f
出典データセット
uspto-grants-2004_06
特許番号
US06747023B1

反応ノート

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