참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | Methyl 4-acetylbenzoate | HCID 137990 | — |
| 용매 | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| 생성물 | Methyl 4-(2-bromoacetyl)benzoate | HCID 13612771 | 71% |
반응 단계
At 15° C., methyl 4-acetylbenzoate (2.23 g) was dissolved in a hydrobromic acid acetic acid solution (30%, 10 ml). Bromine was gradually added dropwise to the reaction mixture to maintain its temperature at 15° C. After stirring for 10 minutes, the reaction mixture was cooled to 4° C. A mixed solvent of methanol (50 ml) and water (50 ml) was added to the reaction mixture for crystallization, followed by washing with hexane. By the collection through filtration, the title compound (2.29 g, 71%) was obtained as a colorless solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06747023B1 |
|---|
| 출처 데이터셋 | uspto-grants-2004_06 |
|---|
| ORD ID | ord-a9cb4e1b76974033ace9847fa2618d0f |
|---|
| 출처 메모 | uspto-grants-2004_06 |
|---|
