4-(Diethylboranyl)pyridine → 1-[2-tert-Butoxycarbonyl-4-(pyridin-4-yl)benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride
Reaction equation
Br[C:2]1[CH:29]=[CH:28][C:5]([C:6]([N:8]2[CH2:13][CH2:12][N:11]([S:14]([C:17]3[CH:26]=[CH:25][C:24]4[C:19](=[CH:20][CH:21]=[C:22]([Cl:27])[CH:23]=4)[CH:18]=3)(=[O:16])=[O:15])[CH2:10][CH2:9]2)=[O:7])=[C:4]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH:3]=1.C(B(CC)[C:40]1[CH:45]=[CH:44][N:43]=[CH:42][CH:41]=1)C>>[ClH:27].[C:33]([O:32][C:30]([C:4]1[CH:3]=[C:2]([C:40]2[CH:45]=[CH:44][N:43]=[CH:42][CH:41]=2)[CH:29]=[CH:28][C:5]=1[C:6]([N:8]1[CH2:9][CH2:10][N:11]([S:14]([C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([Cl:27])[CH:23]=3)[CH:18]=2)(=[O:16])=[O:15])[CH2:12][CH2:13]1)=[O:7])=[O:31])([CH3:36])([CH3:34])[CH3:35]Participants
3
Procedure
In the same manner as in Referential Example 7, a reaction was conducted using 1-[4-bromo-2-(tert-butoxycarbonyl)benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine and diethyl(4-pyridyl)borane as starting materials, whereby the title compound was obtained.
Sources & evidence
- ORD record
- ord-39f9d244ff6248faa11c697752b1f847
- Source dataset
- uspto-grants-2004_06
- Patent number
- US06747023B1
Reaction notes
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