Methyl 4-((((1,1-dimethylethoxy)carbonyl)amino)methyl)benzoate → 1-[4-(N-tert-Butoxycarbonylaminomethyl)benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine

HRID 352743Notes

Reaction equation

HRID 352743 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=O)=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[Cl:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[CH:28]=[C:27]([S:32]([N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1)(=[O:34])=[O:33])[CH:26]=[CH:25]2>>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([C:14]([N:38]2[CH2:37][CH2:36][N:35]([S:32]([C:27]3[CH:26]=[CH:25][C:24]4[C:29](=[CH:30][CH:31]=[C:22]([Cl:21])[CH:23]=4)[CH:28]=3)(=[O:34])=[O:33])[CH2:40][CH2:39]2)=[O:16])=[CH:18][CH:19]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 14221817Methyl 4-((((1,1-dimethylethoxy)carbonyl)amino)methyl)benzoateHCID 227097661-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochloride

Product 1

HCID 227105521-[4-(N-tert-Butoxycarbonylaminomethyl)benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine

Procedure

In the same manner as in Referential Example 48, a reaction was conducted using methyl 4-(N-tert-butoxycarbonylaminomethyl)benzoate and 1-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride, whereby the title compound was obtained.

Sources & evidence

ORD record
ord-921bd6c0acbb408fb23d3121e240c5c7
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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