Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 352743Generated: October 25, 2026

Methyl 4-((((1,1-dimethylethoxy)carbonyl)amino)methyl)benzoate → 1-[4-(N-tert-Butoxycarbonylaminomethyl)benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine

https://huagongshe.com/reaction/352743

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-((((1,1-dimethylethoxy)carbonyl)amino)methyl)benzoateHCID 14221817—
Reactant1-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochlorideHCID 22709766—
Product1-[4-(N-tert-Butoxycarbonylaminomethyl)benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazineHCID 22710552—

Reaction Steps

In the same manner as in Referential Example 48, a reaction was conducted using methyl 4-(N-tert-butoxycarbonylaminomethyl)benzoate and 1-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride, whereby the title compound was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06747023B1
Source datasetuspto-grants-2004_06
ORD IDord-921bd6c0acbb408fb23d3121e240c5c7
Source noteuspto-grants-2004_06