Benzoic acid, 4-(aminoiminomethyl)-, ethyl ester, hydrochloride (1:1) → 4-Carbamimidoylbenzoic acid

Participants

Reaction Steps

In 1N hydrochloric acid (100 ml), the resulting ethyl 4-amidinobenzoate hydrochloride (3.00 g) was dissolved at room temperature, followed by heating under reflux for 2 hours. The solvent was then distilled off under reduced pressure. Colorless crystalline powder so precipitated was collected by filtration and washed with a small amount of tetrahydrofuran, whereby the title compound (2.69 g, 94%) was obtained.

Provenance & Evidence