反应详情

温度

110 °C

Under an argon gas, 4-(4-methylphenyl)pyridine (2.74 g) was dissolved in N,N-dimethylaniline (10 ml), followed by the addition of sodium amide (1.40 g) at room temperature. After the resulting mixture was stirred at 110° C. for 2 days, the reaction mixture was cooled to room temperature. Brown powder precipitated by the addition of water was collected by filtration. The powder was further purified by chromatography on a silica gel column (ethyl acetate:toluene=1:1). After concentration of the resulting fraction, hexane was added and powder thus precipitated was collected by filtration and dried, whereby the title compound (1.40 g, 47%) was obtained.

1. temperaturethe reaction mixture was cooled to room temperature
2. customBrown powder precipitated by the addition of water
3. filtrationwas collected by filtration
4. customThe powder was further purified by chromatography on a silica gel column (ethyl acetate:toluene=1:1)
5. additionAfter concentration of the resulting fraction, hexane was added
6. custompowder thus precipitated
7. filtrationwas collected by filtration
8. customdried