Carbon Dioxide → HCID 23674322, compound

HRID 352810Notes

Reaction equation

HRID 352810 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:11][CH:10]=[N:9][CH:8]=2)=[CH:3][CH:2]=1.CCCCCC.C([Li:22])CCC.[C:23](=[O:25])=[O:24]>C(OCC)C>[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:11][C:10]([C:23]([O-:25])=[O:24])=[N:9][CH:8]=2)=[CH:3][CH:2]=1.[Li+:22]

Participants

6

Reactant 4

HCID 280Carbon DioxideHCID 8058HexaneHCID 22710190HCID 22710190, compoundHCID 178418339Butyllithium

Product 1

HCID 23674322HCID 23674322, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

In diethyl ether (20 ml) was dissolved 5-(pyridin-4-yl)thiazole (290 mg), followed by the dropwise addition of an n-hexane solution (1.54M, 1.20 ml) of n-butyl lithium at −78° C. The resulting mixture was stirred for 10 minutes. After a carbon dioxide gas was blown into the reaction mixture at −78° C. for 15 minutes, the reaction mixture was heated to room temperature. The reaction mixture was concentrated under reduced pressure, whereby the title compound (409 mg) was obtained as a pale brown foam.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure, whereby the title compound (409 mg)
  2. customwas obtained as a pale brown foam

Sources & evidence

ORD record
ord-c58def667dbc4753a6efb1568ec6a5ed
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

Loading…