Carbon Dioxide → HCID 23674322, compound

Participants

Reaction Steps

In diethyl ether (20 ml) was dissolved 5-(pyridin-4-yl)thiazole (290 mg), followed by the dropwise addition of an n-hexane solution (1.54M, 1.20 ml) of n-butyl lithium at −78° C. The resulting mixture was stirred for 10 minutes. After a carbon dioxide gas was blown into the reaction mixture at −78° C. for 15 minutes, the reaction mixture was heated to room temperature. The reaction mixture was concentrated under reduced pressure, whereby the title compound (409 mg) was obtained as a pale brown foam.

Provenance & Evidence