Trifluoroacetic acid → HCID 22710007, compound

HRID 352813Notes

Reaction equation

HRID 352813 reaction equation
[C:1]([O:4][C:5]1[C:6](=[O:41])[CH:7]=[C:8]([CH2:11][NH:12][C:13]([CH:15]2[CH2:20][N:19]([S:21]([C:24]3[NH:25][C:26]4[C:31]([CH:32]=3)=[CH:30][C:29]([Cl:33])=[CH:28][CH:27]=4)(=[O:23])=[O:22])[CH2:18][CH2:17][N:16]2C(OC(C)(C)C)=O)=[O:14])[O:9][CH:10]=1)(=[O:3])[CH3:2].[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45]>C(Cl)Cl>[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45].[C:1]([O:4][C:5]1[C:6](=[O:41])[CH:7]=[C:8]([CH2:11][NH:12][C:13]([CH:15]2[NH:16][CH2:17][CH2:18][N:19]([S:21]([C:24]3[NH:25][C:26]4[C:31]([CH:32]=3)=[CH:30][C:29]([Cl:33])=[CH:28][CH:27]=4)(=[O:23])=[O:22])[CH2:20]2)=[O:14])[O:9][CH:10]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22709922HCID 22709922, compound

Product 1

HCID 22710007HCID 22710007, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In methylene chloride (5 ml), 2-[N-[(5-acetoxy-4-oxo-4H-pyran-2-yl)methyl]carbamoyl]-1-(tert-butoxycarbonyl)-4-[(5-chloroindol-2-yl)sulfonyl]piperazine was treated with trifluoroacetic acid (5 ml), followed by concentration to dryness under reduced pressure, whereby the title compound (224 mg) was obtained.

Workup

  1. concentrationfollowed by concentration to dryness under reduced pressure, whereby the title compound (224 mg)
  2. customwas obtained

Sources & evidence

ORD record
ord-8b7fc5580d2842f985149e2572778d95
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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