反应详情

Ethyl thiooxamate (172 mg) was suspended in ethanol (5 ml) at 0° C., followed by the addition of hydrazine monohydrate (63 μl). While the resulting gas was suctioned, the resulting mixture was stirred for 30 minutes. Ethyl (pyridin-4-yl)glyoxylate hydrate (254 mg) was added to the reaction mixture and the mixture was stirred at room temperature for 30 minutes. After heating under reflux for 4 hours, the reaction mixture was concentrated. The yellow powder thus precipitated was collected by filtration and dried, whereby the title compound (140 mg) was obtained.

1. stirringthe mixture was stirred at room temperature for 30 minutes
2. temperatureAfter heating
3. temperatureunder reflux for 4 hours
4. concentrationthe reaction mixture was concentrated
5. customThe yellow powder thus precipitated
6. filtrationwas collected by filtration
7. customdried