反应详情

Diisopropylethylamine (4.00 ml) was added to a solution of 4-bromobenzenesulfonyl chloride (3.00 g) and 1-(tert-butoxycarbonyl)piperazine (2.40 g) in methylene chloride (50 ml) at room temperature. After stirring at room temperature for 30 minutes, the reaction mixture was concentrated under reduced pressure. The residue thus obtained was purified by chromatography on a silica gel column (hexane:ethyl acetate=4:1→1:1), followed by reprecipitation in a hexane—methylene chloride system, whereby the title compound (4.47 g) was obtained as a colorless solid.

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. customThe residue thus obtained
3. customwas purified by chromatography on a silica gel column (hexane:ethyl acetate=4:1→1:1)
4. customfollowed by reprecipitation in a hexane—methylene chloride system, whereby the title compound (4.47 g)
5. customwas obtained as a colorless solid