Hydrochloric Acid → HCID 22710891, compound

HRID 352829Notes

Reaction equation

HRID 352829 reaction equation
C(Cl)[Cl:2].C(OC([N:11]1[CH2:16][CH2:15][N:14]([S:17]([C:20]2[CH:29]=[CH:28][C:27]3[C:22](=[CH:23][CH:24]=[C:25]([Cl:30])[CH:26]=3)[CH:21]=2)(=[O:19])=[O:18])[C:13]([CH3:32])([CH3:31])[CH2:12]1)=O)(C)(C)C.Cl>C(O)C>[ClH:2].[Cl:30][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[CH:21]=[C:20]([S:17]([N:14]1[CH2:15][CH2:16][NH:11][CH2:12][C:13]1([CH3:32])[CH3:31])(=[O:18])=[O:19])[CH:29]=[CH:28]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 22710468HCID 22710468, compound

Product 1

HCID 22710891HCID 22710891, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a methylene chloride solution (0.5 ml) of 4-(tert-butoxycarbonyl)-1-[(6-chloronaphthalen-2-yl)sulfonyl]-2,2-dimethylpiperazine (140 mg) was added a saturated solution (0.5 ml) of hydrochloride in ethanol. The resulting mixture was stirred at room temperature for 14 hours. Ethanol was added to the reaction mixture. After the sufficient removal of hydrochloric acid by azeotropy, the residue was dried using a vacuum pump, whereby the title compound (119 mg) was obtained as a colorless solid.

Workup

  1. customAfter the sufficient removal of hydrochloric acid by azeotropy
  2. customthe residue was dried
  3. customwas obtained as a colorless solid

Sources & evidence

ORD record
ord-5bf41e35a2034df1a2604a158769b80f
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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