Sodium Hydroxide → Sodium thiazolo[5,4-c]pyridine-2-carboxylate

HRID 352844Notes

Reaction equation

HRID 352844 reaction equation
[N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[S:3][C:2]=1[C:10]([O:12]CC)=[O:11].[OH-].[Na+:16]>O1CCCC1>[N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[S:3][C:2]=1[C:10]([O-:12])=[O:11].[Na+:16]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14252940Ethyl thiazolo[5,4-c]pyridine-2-carboxylate

Product 1

HCID 23694146Sodium thiazolo[5,4-c]pyridine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl thiazolo[5,4-c]pyridine-2-carboxylate (J. Heterocyclic Chem., 27, 563(1990) (0.61 g) was dissolved in tetrahydrofuran (12 ml). To the resulting solution, a 1N aqueous sodium hydroxide solution (3 ml) was added, followed by stirring at room temperature for 30 minutes. The insoluble matter was collected by filtration. Without purification, it was provided for the subsequent reaction as it was.

Workup

  1. filtrationThe insoluble matter was collected by filtration
  2. customWithout purification
  3. customit was provided for the subsequent reaction as it

Sources & evidence

ORD record
ord-0b315840b8124e289e84b827b1f085c8
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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