Morpholine → 1-[(6-Chloronaphthalen-2-yl)sulfonyl]-3-[[(morpholin-4-yl)carbonyl]methyl]piperazine Hydrochloride
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([Cl:27])[CH:23]=3)[CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH:9]1[CH2:28][C:29]([OH:31])=O)=O)(C)(C)C.[NH:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[ClH:27].[Cl:27][C:22]1[CH:23]=[C:24]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[C:17]([S:14]([N:11]1[CH2:12][CH2:13][NH:8][CH:9]([CH2:28][C:29]([N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)=[O:31])[CH2:10]1)(=[O:16])=[O:15])[CH:26]=[CH:25]2Participants
3
Procedure
In the same manner as in Referential Example 319, an amid bond was formed using 1-tert-butoxycarbonyl-2-carboxymethyl-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine and morpholine as starting materials, followed by deprotection In the same manner as in Referential Example 1, whereby the title compound was obtained.
Workup
- customIn the same manner as in Referential Example 319, an amid bond was formed
Sources & evidence
- ORD record
- ord-c4105d263cd34f0996b15ccd05a2698a
- Source dataset
- uspto-grants-2004_06
- Patent number
- US06747023B1
Reaction notes
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