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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 352862Generated: October 30, 2026

Morpholine → 1-[(6-Chloronaphthalen-2-yl)sulfonyl]-3-[[(morpholin-4-yl)carbonyl]methyl]piperazine Hydrochloride

https://huagongshe.com/reaction/352862

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
Reactant1-Tert-butoxycarbonyl-2-carboxymethyl-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazineHCID 22710062—
Product1-[(6-Chloronaphthalen-2-yl)sulfonyl]-3-[[(morpholin-4-yl)carbonyl]methyl]piperazine HydrochlorideHCID 22709535—

Reaction Steps

In the same manner as in Referential Example 319, an amid bond was formed using 1-tert-butoxycarbonyl-2-carboxymethyl-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine and morpholine as starting materials, followed by deprotection In the same manner as in Referential Example 1, whereby the title compound was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06747023B1
Source datasetuspto-grants-2004_06
ORD IDord-c4105d263cd34f0996b15ccd05a2698a
Source noteuspto-grants-2004_06