Sodium Acetate → HCID 22711152, compound

HRID 352890Notes

Reaction equation

HRID 352890 reaction equation
Cl[C:2]1[S:3][C:4]2[CH2:10][C:9]3([O:14][CH2:13][CH2:12][O:11]3)[CH2:8][CH2:7][C:5]=2[N:6]=1.C([O-])(=O)C.[Na+]>CO.[C].[Pd]>[CH2:13]1[CH2:12][O:11][C:9]2([CH2:8][CH2:7][C:5]3[N:6]=[CH:2][S:3][C:4]=3[CH2:10]2)[O:14]1

Participants

5

Reactant 2

HCID 517045Sodium AcetateHCID 227102672-Chloro-4,7-dihydrospiro[benzothiazole-6(5H),2′-[1,3]dioxolane]

Product 1

HCID 22711152HCID 22711152, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

In a 100-mL egg-plant type flask, 2-chloro-6,6-ethylenedioxy-4,5,6,7-tetrahydrobenzo[d]thiazole (860 mg) was charged and was dissolved in methanol (10 mL). To the resulting solution were added 10% palladium-carbon (100 mg) and sodium acetate (305 mg), followed by stirring under a hydrogen gas stream of 4.5 atmospheric pressure. After 17 hours, palladium was filtered off and the solvent was distilled off under reduced pressure. The residue was subjected to chromatography on a silica gel column (silica gel: 50 g, ethyl acetate:hexane=1:1), whereby the title compound (720 mg) was obtained as a pale yellow oil.

Workup

  1. filtrationpalladium was filtered off
  2. distillationthe solvent was distilled off under reduced pressure
  3. customwas obtained as a pale yellow oil

Sources & evidence

ORD record
ord-b0b5d1bc8da64f8eb980498ea5bebe24
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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