Sodium Acetate → HCID 22711152, compound

Participants

Reaction Steps

In a 100-mL egg-plant type flask, 2-chloro-6,6-ethylenedioxy-4,5,6,7-tetrahydrobenzo[d]thiazole (860 mg) was charged and was dissolved in methanol (10 mL). To the resulting solution were added 10% palladium-carbon (100 mg) and sodium acetate (305 mg), followed by stirring under a hydrogen gas stream of 4.5 atmospheric pressure. After 17 hours, palladium was filtered off and the solvent was distilled off under reduced pressure. The residue was subjected to chromatography on a silica gel column (silica gel: 50 g, ethyl acetate:hexane=1:1), whereby the title compound (720 mg) was obtained as a pale yellow oil.

Provenance & Evidence