反应详情

To a stirred solution of 1.5 mmol of 2-methylbenzoyl chloride in 10 ml of methylene chloride is added 3 mmol of triethylamine. After stirring for 15 minutes, 1.5 mmol of 4,5-dihydro-5-(4-aminobenzoyl)pyrrolo[1,2-a]quinoxaline is added and the mixture stirred for 5 hours. The reaction mixture is washed with water, 1N HCl, NaHCO3, and brine. The reaction mixture is dried with Na2 SO4, filtered and evaporated in vacuo to give a solid which is purified by flash chromatography to give the desired product as a solid, m.p. 206°-207° C.

1. stirringthe mixture stirred for 5 hours
2. washThe reaction mixture is washed with water, 1N HCl, NaHCO3, and brine
3. customThe reaction mixture is dried with Na2 SO4
4. filtrationfiltered
5. customevaporated in vacuo
6. customto give a solid which
7. customis purified by flash chromatography