Sodium Hydroxide → HCID 22710479, compound

HRID 352932Notes

Reaction equation

HRID 352932 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:8]=[N:9][C:10]([C:13]([O:15]CC)=[O:14])=[CH:11][N:12]=2)=[CH:3][CH:2]=1.[OH-].[Na+]>O1CCCC1.CO>[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:8]=[N:9][C:10]([C:13]([OH:15])=[O:14])=[CH:11][N:12]=2)=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 22711342Ethyl 3-(pyridin-4-yl)-1,2,4-triazin-6-carboxylate

Product 1

HCID 22710479HCID 22710479, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Ethyl 3-(pyridin-4-yl)-1,2,4-triazin-6-carboxylate (200 mg) was dissolved in a mixed solvent of tetrahydrofuran (5 ml) and methanol (5 ml) at room temperature. A 1N aqueous solution (1.00 ml) of sodium hydroxide was added to the reaction mixture in one portion. After stirring for 5 minutes, the reaction mixture was distilled under reduced pressure to remove tetrahydrofuran and methanol, followed by neutralization with 1N hydrochloric acid. The reaction mixture was concentrated to dryness, whereby 3-(pyridin-4-yl)-1,2,4-triazine-6-carboxylic acid was obtained as a crudely purified product.

Workup

  1. distillationthe reaction mixture was distilled under reduced pressure
  2. customto remove tetrahydrofuran and methanol
  3. concentrationThe reaction mixture was concentrated to dryness

Sources & evidence

ORD record
ord-d88c9ea7b4284f8facda13a7ea18324c
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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