Hydrochloric Acid → HCID 22711005, compound

HRID 352967Notes

Reaction equation

HRID 352967 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]2[N:14]([CH3:39])[C:15]([C:17]([N:19]3[CH2:24][CH2:23][N:22]([S:25]([C:28]4[CH:37]=[CH:36][C:35]5[C:30](=[CH:31][CH:32]=[C:33]([Cl:38])[CH:34]=5)[CH:29]=4)(=[O:27])=[O:26])[CH2:21][CH2:20]3)=[O:18])=[CH:16][C:10]=2[CH2:9]1)=O)(C)(C)C.Cl>C(O)C>[ClH:38].[Cl:38][C:33]1[CH:34]=[C:35]2[C:30](=[CH:31][CH:32]=1)[CH:29]=[C:28]([S:25]([N:22]1[CH2:23][CH2:24][N:19]([C:17]([C:15]3[N:14]([CH3:39])[C:11]4[CH2:12][CH2:13][NH:8][CH2:9][C:10]=4[CH:16]=3)=[O:18])[CH2:20][CH2:21]1)(=[O:27])=[O:26])[CH:37]=[CH:36]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22710962HCID 22710962, compound

Product 1

HCID 22711005HCID 22711005, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 5-(t-butoxycarbonyl)-2-[[4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazin-1-yl]carbonyl]-1-methyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine (280 mg), a saturated solution hydrochloride in ethanol (25 ml) was added at room temperature, followed by stirring for 1 hour. The reaction mixture was then concentrated. Water (10 ml) was added to the concentrate, followed by concentration under reduced pressure, whereby the title compound (210 mg) was obtained as a white solid.

Workup

  1. concentrationThe reaction mixture was then concentrated
  2. additionWater (10 ml) was added to the concentrate
  3. concentrationfollowed by concentration under reduced pressure, whereby the title compound (210 mg)
  4. customwas obtained as a white solid

Sources & evidence

ORD record
ord-3200476b00c04a39931124bddb6b9753
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

Loading…