反应详情

A mixture of 35 g (0.18 mol) of 2-ethylhexyl cyanoacetate and 30 g (0.18 mol) of 4-acetamidobenzaldehyde in 300 ml of isopropanol is refluxed for 3 hours. The reaction mixture is then allowed to cool and is crystallized. The crystals formed are separated out by filtration and are recrystallized from a minimum amount of isopropanol. After filtration and drying, 33.3 g (54% yield) of 2-ethylhexyl 3-(4-acetylaminophenyl)-2-cyanoacrylate are obtained in the form of a pale yellow powder.

1. temperatureis refluxed for 3 hours
2. temperatureto cool
3. customis crystallized
4. customThe crystals formed
5. customare separated out by filtration
6. customare recrystallized from a minimum amount of isopropanol
7. filtrationAfter filtration
8. customdrying