HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 12075954, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Furan, 2-(bromomethyl)tetrahydro- | HCID 14501 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 12075954 | HCID 12075954 | 92% |
Reaction Steps
A mixture of 165 g of tetrahydrofurfuryl bromide, 348 g of morpholine, 5 g of sodium iodide and 500 g of tetrahydrofuran was heated under reflux for 50 hours. After cooling, diethyl ether was added to the reaction solution, which was filtered, concentrated in vacuum and purified by vacuum distillation, whereby 158 g of 4-tetrahydrofurfuryl-morpholine, designated [B-44], was obtained (boiling point 64° C./15 Pa, yield: 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06749988B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-0eebf0fdf0d74d46b7db2de1805ac748 |
| Source note | uspto-grants-2004_06 |