Sodium Iodide → HCID 12075954, compound

HRID 353014Notes

Reaction equation

HRID 353014 reaction equation
[CH2:1](Br)[CH:2]1[O:6][CH2:5][CH2:4][CH2:3]1.[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[I-].[Na+].O1CCCC1>C(OCC)C>[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)[CH:2]1[O:6][CH2:5][CH2:4][CH2:3]1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 8028TetrahydrofuranHCID 8083MorpholineHCID 14501Furan, 2-(bromomethyl)tetrahydro-

Product 1

HCID 12075954HCID 12075954, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 165 g of tetrahydrofurfuryl bromide, 348 g of morpholine, 5 g of sodium iodide and 500 g of tetrahydrofuran was heated under reflux for 50 hours. After cooling, diethyl ether was added to the reaction solution, which was filtered, concentrated in vacuum and purified by vacuum distillation, whereby 158 g of 4-tetrahydrofurfuryl-morpholine, designated [B-44], was obtained (boiling point 64° C./15 Pa, yield: 92%).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 50 hours
  3. temperatureAfter cooling
  4. filtrationwas filtered
  5. concentrationconcentrated in vacuum
  6. distillationpurified by vacuum distillation, whereby 158 g of 4-tetrahydrofurfuryl-morpholine
  7. customwas obtained (boiling point 64° C./15 Pa, yield: 92%)

Sources & evidence

ORD record
ord-0eebf0fdf0d74d46b7db2de1805ac748
Source dataset
uspto-grants-2004_06
Patent number
US06749988B2

Reaction notes

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