Benzyl chloroformate → 3-[N-benzyloxycarbonyl-N-(1-oxido-2-pyridinyl)amino] propanol

HRID 353036Notes

Reaction equation

HRID 353036 reaction equation
[O-:1][N+:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][CH2:9][CH2:10][CH2:11][OH:12].Cl[C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15]>>[CH2:17]([O:16][C:14]([N:8]([CH2:9][CH2:10][CH2:11][OH:12])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][N+:2]=1[O-:1])=[O:15])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 10387Benzyl chloroformateHCID 178526251HCID 178526251, compound

Product 1

HCID 219625733-[N-benzyloxycarbonyl-N-(1-oxido-2-pyridinyl)amino] propanol

Procedure

3-[N-benzyloxycarbonyl-N-(1-oxido-2-pyridinyl)amino] propanol was prepared by reaction of 3-[N-(1-oxido-2-pyridinyl)amino] propanol (obtained as described in MILLER, W. H. et al. Bioorg. Med. Chem. Lett. 1999, 9 1807-1812) with benzyl chloroformate according to the standard procedure.

Sources & evidence

ORD record
ord-7c58daa1582344538052843179203d23
Source dataset
uspto-grants-2004_06
Patent number
US06750215B2

Reaction notes

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