反应详情

39.6 Parts of 1-(4-fluorophenyl)-1,3-dihydro-1-[3-(tetrahydro-2H-pyran-2-yloxy)propyl]isobenzofuran were dissolved in 9.8 parts of a hydrochloric acid solution 0.1M and 788 parts of ethanol and the whole was stirred and refluxed for one hour. The solvent was evaporated and the residue was taken up in methylbenzene and water. The organic phase was separated, washed with water, dried, filtered and evaporated. The residue was purified by column-chromatography over silica gel using a mixture trichloromethane and methanol (99:1 by volume) as eluent. The pure fractions were collected and the eluent was evaporated, yielding 24.2 parts of 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-propanol as a residue (intermediate 11).

1. temperaturerefluxed for one hour
2. customThe solvent was evaporated
3. customThe organic phase was separated
4. washwashed with water
5. customdried
6. filtrationfiltered
7. customevaporated
8. customThe residue was purified by column-chromatography over silica gel using a mixture trichloromethane and methanol (99:1 by volume) as eluent
9. customThe pure fractions were collected
10. customthe eluent was evaporated