HCID 178486092, compound → HCID 178486091, compound

HRID 353057Notes

Reaction equation

HRID 353057 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-])=O.[CH3:11][N:12]([CH3:16])[SH:13](=[O:15])=[O:14]>C(O)C.[Ni]>[NH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[CH3:1].[CH3:11][N:12]([CH3:16])[SH:13](=[O:15])=[O:14]

Participants

4

Reactant 1

HCID 178486092HCID 178486092, compound

Product 1

HCID 178486091HCID 178486091, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

The compound 4-methyl-3-nitro-benzene-N,N-dimethylsulfonamide is dissolved in ethanol. A catalyst like Raney nickel is added and the mixture hydrogenated in a shaker. The catalyst is removed by filtration. The solvent is removed in vacuo to give a product which may be purified if necessary by chromatography or crystallization from an appropriate solvent like chloroform or heptane-ethyl acetate.

Workup

  1. customThe catalyst is removed by filtration
  2. customThe solvent is removed in vacuo
  3. customto give a product which
  4. custommay be purified if
  5. customnecessary by chromatography or crystallization from an appropriate solvent like chloroform or heptane-ethyl acetate

Sources & evidence

ORD record
ord-c3f4191d7f0a491baafd4427f8094f1c
Source dataset
uspto-grants-2004_06
Patent number
US06750217B2

Reaction notes

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