Calciumoxide → N-(2-Hydroxyethyl)piperazine-2-carboxamide

HRID 35314Notes

Reaction equation

HRID 35314 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5]([C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1)=[O:6].[O-2].[Ca+2].[H][H]>[Pd].COCCO>[OH:1][CH2:2][CH2:3][NH:4][C:5]([CH:7]1[CH2:12][NH:11][CH2:10][CH2:9][NH:8]1)=[O:6]

Participants

6

Reactant 3

HCID 6850728CalciumoxideHCID 14230272N-(2-Hydroxyethyl)pyrazine-2-carboxamideHCID 178418361HCID 178418361, compound

Product 1

HCID 21295693N-(2-Hydroxyethyl)piperazine-2-carboxamideYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 80192-MethoxyethanolSolvent

Procedure

A mixture of 53.7 parts of N-(2-hydroxyethyl)-2-pyrazinecarboxamide, 20 parts of calcium oxide and 500 parts of 2-methoxyethanol was hydrogenated at normal pressure and at room temperature with 5 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 55.4 parts (100%) of N-(2-hydroxyethyl)-2-piperazinecarboxamide as a residue (intermediate 23).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-b56d601a4dce45e6ae90674d9452c29c
Source dataset
uspto-grants-1988_08
Patent number
US04766125

Reaction notes

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