HuagongsheHuagongshe Chemistry Print Report · For research reference only
Calciumoxide → N-(2-Hydroxyethyl)piperazine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Calciumoxide | HCID 6850728 | — |
| Reactant | N-(2-Hydroxyethyl)pyrazine-2-carboxamide | HCID 14230272 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | N-(2-Hydroxyethyl)piperazine-2-carboxamide | HCID 21295693 | 100% |
Reaction Steps
A mixture of 53.7 parts of N-(2-hydroxyethyl)-2-pyrazinecarboxamide, 20 parts of calcium oxide and 500 parts of 2-methoxyethanol was hydrogenated at normal pressure and at room temperature with 5 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 55.4 parts (100%) of N-(2-hydroxyethyl)-2-piperazinecarboxamide as a residue (intermediate 23).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04766125 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-b56d601a4dce45e6ae90674d9452c29c |
| Source note | uspto-grants-1988_08 |