Trifluoroacetic acid → HCID 22708233, compound

HRID 353174Notes

Reaction equation

HRID 353174 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([CH:12]([NH:15][CH2:16][C:17]1[CH:33]=[CH:32][C:20]([O:21][C:22]([CH3:31])([CH3:30])[C:23]([O:25]C(C)(C)C)=[O:24])=[CH:19][CH:18]=1)[CH2:13][CH3:14])=[O:11].FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([CH:12]([NH:15][CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:21][C:22]([CH3:30])([CH3:31])[C:23]([OH:25])=[O:24])=[CH:32][CH:33]=1)[CH2:13][CH3:14])=[O:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22708251HCID 22708251, compound

Product 1

HCID 22708233HCID 22708233, compoundYield 75.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Similarly to the procedure of Example 1-9, 170 mg (0.374 mmol) of tert-butyl 2-(4-{[(1-{[(2,4-dimethylphenyl)amino]carbonyl}propyl)amino]methyl}phenoxy)-2-methylpropionate (Example 1-7) are reacted with 0.72 ml (9.35 mmol) of trifluoroacetic acid in 3 ml of dichloromethane to give 113 mg (72%) of 2-(4-{[(1-{[(2,4-dimethylphenyl)amino]carbonyl}propyl)amino]methyl}phenoxy)-2-methylpropionic acid.

Sources & evidence

ORD record
ord-11600da4cb854431a17b6ee161ca8530
Source dataset
uspto-grants-2004_06
Patent number
US06750236B2

Reaction notes

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