Trifluoroacetic acid → HCID 22708290, compound

HRID 353185Notes

Reaction equation

HRID 353185 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([CH3:10])=[CH:4][C:3]=1[NH:11][C:12](=[O:39])[CH2:13][N:14]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([S:28][C:29]([CH3:38])([CH3:37])[C:30]([O:32]C(C)(C)C)=[O:31])=[CH:24][CH:23]=1)[CH2:15][C:16]1[O:17][CH:18]=[CH:19][CH:20]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([CH3:10])=[CH:4][C:3]=1[NH:11][C:12](=[O:39])[CH2:13][N:14]([CH2:21][C:22]1[CH:23]=[CH:24][C:25]([S:28][C:29]([CH3:37])([CH3:38])[C:30]([OH:32])=[O:31])=[CH:26][CH:27]=1)[CH2:15][C:16]1[O:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22708186HCID 22708186, compound

Product 1

HCID 22708290HCID 22708290, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

190 mg of tert-butyl 2-[[4-[[[2-[(2,5-dimethyl-4-methoxyphenyl)amino]-2-oxoethyl](2-furanyl-methyl)amino]methyl]phenyl]thio]-2-methyl-propanoate are dissolved in 5 ml of dichloromethane and reacted with 1 ml of trifluoroacetic acid. The mixture is stirred at room temperature for 20 h and then concentrated and purified chromatographically (dichloromethane/methanol 50+1). This gives 166 mg of the title compound as a solid foam.

Workup

  1. concentrationconcentrated
  2. custompurified chromatographically (dichloromethane/methanol 50+1)

Sources & evidence

ORD record
ord-85af5a91f992424488d1ac319514e48a
Source dataset
uspto-grants-2004_06
Patent number
US06750236B2

Reaction notes

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