Trifluoroacetic acid → HCID 22708244, compound

HRID 353186Notes

Reaction equation

HRID 353186 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[NH:10][C:11](=[O:38])[CH2:12][N:13]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([S:27][C:28]([CH3:37])([CH3:36])[C:29]([O:31]C(C)(C)C)=[O:30])=[CH:23][CH:22]=1)[CH2:14][C:15]1[O:16][CH:17]=[CH:18][CH:19]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[NH:10][C:11](=[O:38])[CH2:12][N:13]([CH2:20][C:21]1[CH:22]=[CH:23][C:24]([S:27][C:28]([CH3:36])([CH3:37])[C:29]([OH:31])=[O:30])=[CH:25][CH:26]=1)[CH2:14][C:15]1[O:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22708291HCID 22708291, compound

Product 1

HCID 22708244HCID 22708244, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

200 mg of tert-butyl 2-[[4-[[[2-[(2-methyl-4-methoxyphenyl)amino]-2-oxoethyl](2-furanyl-methyl)amino]methyl]phenyl]thio]-2-methyl-propanoate are dissolved in 5 ml of dichloromethane and reacted with 1 ml of trifluoroacetic acid. The mixture is stirred at room temperature for 20 h and then concentrated and purified chromatographically (dichloromethane/methanol 50+1). This gives 174 mg of the title compound as a solid foam.

Workup

  1. concentrationconcentrated
  2. custompurified chromatographically (dichloromethane/methanol 50+1)

Sources & evidence

ORD record
ord-d1063172d3cb4dd699e4977a04e633de
Source dataset
uspto-grants-2004_06
Patent number
US06750236B2

Reaction notes

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