2-Acetylfuran → HCID 535936, compound

HRID 353212Notes

Reaction equation

HRID 353212 reaction equation
[C:1]([C:4]1[O:5][CH:6]=[CH:7][CH:8]=1)(=[O:3])[CH3:2].CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>>[CH3:11][N:12]([CH3:14])[CH:13]=[CH:2][C:1]([C:4]1[O:5][CH:6]=[CH:7][CH:8]=1)=[O:3]

Participants

3

Reactant 2

HCID 145052-AcetylfuranHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 535936HCID 535936, compoundYield 97%

Conditions

Temperature
100 °C

Procedure

A mixture of 2-acetylfuran (25.0 g, 0.227 mmol) and N,N-dimethylformamide dimethylacetal (40 ml) was stirred at 100° C. for 9 hours. After cooling as it was, the reaction solution was concentrated. Diethyl ether and hexane were added to the residue, and the resulting solid was collected by filtration and washed with hexane, to give the title compound (36.5 g, 97%) as a brown solid.

Workup

  1. temperatureAfter cooling as it
  2. concentrationthe reaction solution was concentrated
  3. additionDiethyl ether and hexane were added to the residue
  4. filtrationthe resulting solid was collected by filtration
  5. washwashed with hexane

Sources & evidence

ORD record
ord-f94a5246ce3443b092460200d15c6f49
Source dataset
uspto-grants-2004_06
Patent number
US06750232B2

Reaction notes

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