反应详情

Ethyl (2Z)-3-[4-(benzyloxy)-3-nitrophenyl]-2-ethoxyacrylate (0.83 g, 1.57 mmole) was hydrogenated in ethylacetate (10 ml) at atmospheric pressure using Pd/C (5%) as a catalyst. The mixture was filtered through celite and evaporated in vacuo. Purification of the crude product with preparative HPLC (Kromasil C8, 7 μm, 50×250 mm) using actonitrile(0-60%) in ammonium acetate buffer (pH 7) as mobile phase gave 0.052 g (13% yield) of the desired product.

1. filtrationThe mixture was filtered through celite
2. customevaporated in vacuo
3. customPurification of the crude product with preparative HPLC (Kromasil C8, 7 μm, 50×250 mm)